Professor Zsolt Radák and his research team have made a groundbreaking observation

Lactic acid alters DNA methylation, gene expression, and protein synthesis. In short, this is the essence of the groundbreaking observation recently published by Professor Zsolt Radák and his research team in the journal Redox Biology.

The results of the research group help to explain the observation of the Nobel Prize-winning German biochemist Otto Warburg, who described that cancer cells produce lactic acid even in the presence of oxygen. The researchers at Hungarian University of Sports Science (HUSS) can now explain that lactic acid plays a key role in tumor growth through DNA demethylation. It also becomes clearer why high-intensity exercise—which produces more lactic acid—is such an effective training method.

This study provides further evidence that lactic acid is not merely a metabolic byproduct, but a crucial biological messenger with a complex role in cellular physiology, not only in sports but also in pathophysiological processes. The first author of the article is Lei Zhou, one of the most outstanding PhD students of HUSS’s Doctoral School.

The article, published in the journal Redox Biology with an impact factor of 11.9 and a D1 ranking, is available at this link.

Tags: research,Zsolt Radák

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