Covid-19 research at HUSS on post-vaccination syndrome
August 26, 2025Magyar Testnevelési és Sporttudományi Egyetem

In recent days, an interesting article was published in the journal Vaccines on the adverse side effects of mRNA-LNP-based COVID-19 vaccines, specifically Pfizer-BioNTech Comirnaty and Moderna-Spikevax, by Professor János Szebeni and Professor Ákos Koller, the Chairman of Hungarian University of Sports Science’s (HUSS) Scientific Council.

Although these types of vaccines were successfully introduced to curb the Covid‑19 pandemic, due to adverse events, today the modified forms are recommended only for those exposed to increased health risks – the elderly and people with chronic illnesses. International literature collectively refers to the occurrence of adverse events (AE) as post-vaccination syndrome (PVS).

A prominent manifestation of PVS is a multisystem inflammatory response, which is presumably caused by multiple factors: the mRNA delivered to organs and tissues via lipid nanoparticles (LNP) and the subsequent so-called spike protein production – which acts as a toxin – together trigger this effect.

It appears that the inflammatory reactions – molecular and cellular toxic and autoimmune responses – primarily develop in endothelial cells within the microcirculatory networks of various organs, from which the individual-specific PVS subsequently emerges. A deeper understanding of the mechanisms triggered by mRNA-LNPs, organ- and cellular-level adverse events, and PVS is critical not only for the safe development of this pioneering technology as a vaccine but also for its other therapeutic applications.

Post-Covid‑19 Infection Syndrome

Interestingly, around the same time, perhaps even more notably, an article was published on the research findings of Beáta Gyömörei and colleagues from HUSS in the journal Sport Research International – SPRINT.

The study collected data from 108 young athletes (aged 13–17, 50 girls and 58 boys). Each participant had experienced a documented Covid‑19 infection of varying severity. Cardiological assessments indicated that in unvaccinated young competitive athletes, no signs of myocarditis were found following Covid‑19, meaning that the occurrence of Covid‑19-related myocarditis does not differ from that associated with other non-Covid viral infections. Therefore, in this case as well, similar testing protocols should be applied when returning to sports activity as with other viral illnesses.

The English-language article by Ákos Koller and colleagues can be read here.

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